PROJECTS
b.IMAGE projects
To stimulate new ideas and competencies in the context of the b.IMAGE, INEB granted funding to 3 junior researchers, after an external peer review process:
1. Automated in vitro cell culture segmentation and characterization through data mining
Principal investigator: Pedro Quelhas (Bioimaging Group) Participants: From the Bioimaging Group: Luis Ferro, Marco Marques, Pedro Leal
Summary: Cell segmentation is a fundamental step in the analysis of in vitro cell cultures. This project has, as it main objective, the creation of new approaches to cell culture segmentation using group characterization for segmentation verification. The planned approach will borrow from data mining approaches and based on local interest point detectors will learn the joint characterization of the cell culture to either validate the found cells or to estimate how to adapt the current parameters to obtain a better result.
2. A Bioimaging tool to follow the dynamical behavior of MSCs in 3D microenvironments.
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Principal investigator: Catarina Almeida (NewTherapies Group)
Participants: From the NewTherapies group from INEB: Hugo Caires, Cristina Barrias, Raquel Gonçalves and Maria Lazaro. From the Cancer Genetics group from IPATIMUP: Carla Oliveira and Raquel Seruca.
Summary: Here, we are developing a new Bioimaging tool to follow the dynamics of MSCs in 3D with state-of-the-art confocal microscopy. With this new tool we will track MSCs embedded in matrices composed by different constituents of the Extracellular Matrix (ECM), and in ECM-like matrices.
3. Imaging Flow Cytometry as a tool for Y1R antagonist characterization as a drug for bone regeneration.
Principal investigator: Inês Alencastre (NewTerapies Group, Neuro osteogenesis team)
Participants: Cecilia Juliana Alves, Meriem Lamghari
Summary: Recently, neuropeptide receptors have arisen as potential regulators in the local control of bone turnover. This project aims to explore the potentials of Imaging Flow Cytometry for the characterization of the receptor-antagonist binding within the bone microenvironment and evaluate the antagonist behavior as a drug for bone regeneration.
Other projects involving bioimaging running in the Institute
Assessment of the correlation between retinal and carotid circulation using automatic image analysis
BIOAMD - Biomaterials for modulation of inflammation in Age Related Macular Degeneration
BIOMATRIX: Extracellular matrix-like multifunctional biomaterials for bone regeneration
CHITOSAMP - CHITOSan-AntiMicrobial Peptide-based biomaterials for the treatment of osteomyelitis
DeepNets - Reusable Deep Neural Networks: applications to Biomedical Data
Development and Biological Evaluation of Tissue Engineered Injectable Systems
Development of a Biomaterial Microarray for High-throughput Screening of 3D Cell Cultures
Hybrid Sr-releasing injectable system for vertebroplasty
IB2 - Industrial Biological Biomaterials Doctorate
Macrophage - Effect of radio- and chemotherapy on cancer cell invasion: the role of macrophages
MatriCard - Dissection and Reconstruction of the Extracellular Matrix: A Cardiac Regenerative Niche
MIMESIS: Marine Invertebrates Models & Engineered Substrates for Innovative bio-Scaffolds
NaNOBiofilm - Nanohydroxyapatite antibacterial surfaces to prevent biofilm associated bone infection
Primary Total Hip Replacement: Failure of the Explanted Prostheses Analyses
PYLORICIDAL - Engineered biomaterials with Helicobacter PYLORI bacteriCIDAL effect
Simulation of new disc regeneration therapies in an organ culture
TARGETS - TARgeted GEne Therapy Strategies to treat nerve injury
TUMORTAG - Tumor-targeted nanoparticles for early diagnosis of gastric cancer
